{"id":14,"date":"2021-03-01T13:17:09","date_gmt":"2021-03-01T13:17:09","guid":{"rendered":"https:\/\/genetec.io\/?page_id=14"},"modified":"2021-12-01T22:19:25","modified_gmt":"2021-12-01T22:19:25","slug":"what-is-venture-capital","status":"publish","type":"page","link":"https:\/\/genetec.io\/?page_id=14","title":{"rendered":"TERRA RNA&#8217;s"},"content":{"rendered":"\n<p>From Wikipedia:<\/p>\n\n\n\n<p><strong>TERRA<\/strong>\u00a0in biology is an abbreviation for &#8220;TElomeric Repeat-containing RNA&#8221;.\u00a0TERRA is\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/RNA\">RNA<\/a>\u00a0that is\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Transcription_(genetics)\">transcribed<\/a>\u00a0from\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Telomere\">telomeres<\/a>\u00a0\u2014 the repeating 6-<a href=\"https:\/\/en.wikipedia.org\/wiki\/Nucleotide\">nucleotide<\/a>\u00a0sequences that cap the ends of\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Chromosome\">chromosomes<\/a>. TERRA functions with\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Shelterin\">shelterin<\/a>\u00a0to inhibit telomere lengthening by enzyme\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Telomerase\">telomerase<\/a>.<\/p>\n\n\n\n<p>TERRAs are essential for telomere length and maintenance.&nbsp;At least four factors contribute to telomere maintenance: telomerase, shelterin, TERRA and the&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/CST_Complex\">CST Complex<\/a>.<\/p>\n\n\n\n<p>TERRA can also regulate telomere length by increasing&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Euchromatin\">euchromatin<\/a>&nbsp;formation.&nbsp;On the other hand,&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Nonsense-mediated_decay\">nonsense-mediated decay<\/a>&nbsp;factor enrichment at telomeres may exist to prevent TERRA inhibition of telomerase.&nbsp;TERRA levels vary during the&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Cell_cycle\">cell cycle<\/a>, decreasing during&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/S_phase\">S phase<\/a>, and increasing in the transition from&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/G2_phase\">G2 phase<\/a>&nbsp;to&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/G1_phase\">G1 phase<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>From Wikipedia: TERRA\u00a0in biology is an abbreviation for &#8220;TElomeric Repeat-containing RNA&#8221;.\u00a0TERRA is\u00a0RNA\u00a0that is\u00a0transcribed\u00a0from\u00a0telomeres\u00a0\u2014 the repeating 6-nucleotide\u00a0sequences that cap the ends of\u00a0chromosomes. TERRA functions with\u00a0shelterin\u00a0to inhibit telomere lengthening by enzyme\u00a0telomerase. TERRAs are essential for telomere length and maintenance.&nbsp;At least four factors contribute to telomere maintenance: telomerase, shelterin, TERRA and the&nbsp;CST Complex. TERRA can also regulate telomere [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/genetec.io\/index.php?rest_route=\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genetec.io\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/genetec.io\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/genetec.io\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/genetec.io\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14"}],"version-history":[{"count":5,"href":"https:\/\/genetec.io\/index.php?rest_route=\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":63,"href":"https:\/\/genetec.io\/index.php?rest_route=\/wp\/v2\/pages\/14\/revisions\/63"}],"wp:attachment":[{"href":"https:\/\/genetec.io\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}